• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to the use of starch propanoate as a feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth. Starch propanoate acts as a platform for the release of propanoic acid in the intestinal system where fermentation of dietary fiber takes place, passing undigested through the part of the gastrointestinal system where fermentation does not take place before propanoic acid is cleaved in the intestinal system where fermentation of dietary fiber takes place. Released propanoic acid in the gastrointestinal tract stimulates the intestinal wall and promotes the development of the gastrointestinal tract, among other things by increasing the villi length and thus the surface of the intestine and the cell density of the intestinal wall. Thereby, more nutrients will be absorbed. In farm animals, aquaculture animals and fish farming, a healthier gastrointestinal system will promote growth, increase feed utilization, reduce the need for antibiotics and medicinal zinc. Starch propanoate can be used to promote growth, increase feed utilization, prevent the use of antibiotics and medicinal zinc in farm animals, aquaculture animals and fish farming.
    公开号:DK202000169A1
    申请号:DKP202000169
    申请日:2020-02-11
    公开日:2021-11-26
    发明作者:Sander Wilbek Theis；Abildgaard Ole
    申请人:Sander Wilbek Theis；Abildgaard Ole；
    IPC主号:
    专利说明:

    DK 2020 00169 A1 1
    DESCRIPTION The invention relates to the use of starch propanoate as a feed ingredient and / or feed additive for agricultural animals, aquaculture animals and fish farming to promote growth. Starch propanoate as a feed ingredient and / or feed additive can be used to prevent diarrhea, prevent the use of antibiotics and medicinal zinc, increase the utilization of feed and improve the development of the gastrointestinal system in farm animals, aquaculture animals and in fish farming. By starch propanoate is meant starch esterified with propanoic acid to varying degrees. Starch consists of two different polymers - amylose and amylopectin, and can come from different sources - for example from potatoes, rice, wheat and corn. Depending on the source, the ratio of amylose to amylopectin may vary. Amylose is a linear polymer of glucose put together via α-1,4-glycoside bonds of varying length. Amyl-opectin is also a polymer of of glucose units linked via α-1,4-glycoside bonds, but also has branches to other α-1,4-glycoside chains via α-1,6-glycoside bonds. The degree of branching can vary, but is often in the order of 5%.
    15Propanoic acid is one of the three short-chain fatty acids (SCFAs), which are natural energy sources for animals. The three SCFAs are acetic acid, propanoic acid and butanoic acid and are known to have health-promoting effects in animals. SCFAs are mainly formed through the fermentation of dietary fibers by the intestinal bacteria in the intestinal system. There are different types of dietary fiber and not all of them can be fermented. During fermentation of dietary fiber, SCFAs are released, which are thereby absorbed by the intestine and are included as a 20natural energy source. SCFAs also activate various receptors on the intestinal cells, which, among other things, cause peptide hormones, such as GLP1, GLP2 and PPY, to be released. Furthermore, the overall health of the intestine is improved by the release of SCFAs, among other things by increasing the amount of intestinal cells including endocrine cells and L cells.
    25Propanoic acid and butanoic acid have to a greater extent the health-promoting effects in the intestine in relation to acetic acid, as these are more potent as there are several SCFA-binding receptors that are suitable for propanoic and butanoic acid. If acetic acid, propanoic acid or butanoic acid are added directly to the diet, they will be quickly absorbed in the upper part of the gastrointestinal tract and be metabolized. SCFAs admitted to the upper part of the gastrointestinal tract do not promote intestinal development further down the gastrointestinal tract. Thus, the slower release in the lower gastrointestinal tract is essential. This can be achieved by certain intestinal bacteria fermenting dietary fibers that release SCFA in the lower intestinal tract, including especially for mammals in the colon and for aquaculture animals / fish only the lower intestinal tract. The presence of SCFAs in aquaculture animals / fish and farm animals, such as fish, poultry, pigs, cattle and sheep, is essential for the rapid and healthy development of their gastrointestinal tract. SCFA can be added to the feed directly, but this has a reduced effect, as it is absorbed quickly in the stomach and the upper intestine.
    DK 2020 00169 A1 2 channel. In order to achieve a slow release as well as release in the lower intestinal tract, products for agricultural animals, aquaculture animals and fish farming are manufactured and traded, where SCFAs are released slowly in the gastrointestinal tract due to encapsulation / coating, incorporation into triglycides or as salts. This has been shown to reduce diarrhea and the use of antibiotics, promote the growth and utilization of the Saf fed, as well as the development of the gastrointestinal system. The release of SCFAs in the gastrointestinal tract of, for example, pigs has been shown to promote cell division in the intestinal wall and decrease their apoptosis, which net increases the villi length and thus improves the health of the gastrointestinal tract.
    10The amount and ratio of acetic acid, propanoic acid and butanoic acid formed by fermentation in the colon depends on which bacteria are present and to what extent they are present. Ingestion of starch propanoate will not be degraded in the part of the intestinal system where fermentation of dietary fiber does not take place, as the starch is esterified and thus behaves as resistant starch. That is, the release does not occur in the stomach and in the upper intestinal tract. During fermentation in the part of the intestinal system where fermentation takes place, the propanoic acid will be released by hydrolysis - ring of the ester bonds and thus increase the level of propanoic acid in this part of the intestinal system. The de-esterified starch will subsequently be fermented and functionally normal ”fermentable dietary fiber that nourishes the fermenting bacteria.
    The amount of propanoic acid released is increased by this cleavage to a much greater extent than by normal fermentation by normal feeds. Because pigs, fish and other animals for meat breeding are typically treated with medicinal zinc as well as antibiotics to reduce the risk of infections and increase the growth rate, the amount of bacteria in the intestinal tract of the animals is reduced in size and species variation. ability to produce propanoic acid in the upper intestine as a result of bacterial fermentation of dietary fiber inhibits resistant starches. When esterifying starch with propanoic acid, starch propanoate behaves like resistant starch in the gastrointestinal tract, ie. ends up uninterrupted in the colon where it is fermented, but the effect of starch propanoate is far higher than when ingested normally resistant starch. 30g of starch propanoate (with eg 8% propanoic acid and a water content of less than 20%) will selectively increase the amount of propanoic acid in the large intestine by 2 g and in addition also 20 g of starch for possible fermentation. First, the ester is cleaved in the presence of the enzymes for starch and propanoic acid and then the starch is further fermented by the bacteria.
    DK 2020 00169 A1 3 The effect of starch propanoate can thus not be equated with resistant starch and the use and effect described in claims 1-10 thus differ from the use and effect of resistant starch. We thus use starch propanoate to deliver propanoic acid to the part of the intestinal system where fermentation takes place, to achieve the effects described in claims 1-10. The esterbin of the propanoic acid- Sdinger is cleaved and the propanoic acid is released. It is this that mainly increases the amount of propanoic acid and makes it possible to use starch propanoate for claims 1-10. Thus, the main purpose of the esterification of the starch with propanoic acid is not to convert the starch to resistant starch and achieve fermentation thereof, but to achieve release of propanoic acid directly where fermentation in the intestinal system of dietary fiber takes place in larger quantities and regardless of the bacterial flora composition here. . In addition to starch propanoate being a far more effective method of increasing the amount of propanoic acid in the intestinal system in terms of resistant starch and dietary fiber, starch propanoate also ensures an increase in propanoic acid regardless of intestinal flora / bacterial composition.
    It is common knowledge that resistant starch can reduce the use of antibiotics in aquaculture animals / fish and farm animals, but this can also reduce their growth due to reduced intake of degradable starch, as the resistant starch both takes up space in the feed and is not digested to the same degree. and releases energy for metabolism [1]. To avoid this, there are already products 20 on the market that selectively deliver propanoic acid to the gastrointestinal tract without achieving this by fermentation. An example of this is products from Biomin, where propanoic acid is embedded in inorganic phyllo-silicate, thus promoting the growth and feed utilization in animals [2]. However, this is relatively expensive and it can be discussed to what extent propanoic acid is released in the gastrointestinal tract where this is not necessary. Starch propanoate could be used more efficiently for the same purpose and produced much cheaper. Biomin Biotronic gives an off-taste when added to the feed, which can complicate use. Starch propanoate is neutral tasting and does not have this problem. In addition, starch propanoate has the advantage that it more specifically releases propanoic acid where fermentation takes place, and that the remaining starch can be used for fermentation of bacteria and thus included in the diet as a fermentable dietary fiber in aquaculture animals / fish and farm animals. The starting materials and the manufacture of starch propanoate are generally also cheaper and simpler than other products on the market to support the development of the gastrointestinal system in aquaculture animals / fish and farm animals and to reduce the use of antibiotics. Thus, it can be produced and sold cheaper and thus be more accessible and used to a greater extent in agriculture. This is to the benefit of the animals, farmers and society as the use of antibiotics and medicinal zinc will decrease and the animals will be healthier and grow faster. Finally, there is the risk of the high
    DK 2020 00169 A1 4 the use of antibiotics and zinc will lead to a sharp increase in antibiotic-resistant bacteria and restrictions have therefore been introduced in Europe on the use of these in feed for agricultural animals, aquaculture animals and in fish farming. Extended publications
    1. Regassa A, Nyachoti CM. Application of resistant starch in swine and poultry diets with particular reference to good health and function. Anim Nutr. 2018; 4 (3): 305-310. doi: 10.1016 / j.ani- nu.2018.04.001
    102. N. Senkoylu, H. Samli, M. Kanter, et al. Influence of a combination of formic and propionic acids added to wheat- and barley-based diets on the performance and gut histomorphology of broiler chickens. Acta Veterinaria Hungarica 2007 55: 4, 479-490.
    权利要求:
    Claims (3)
    [1]
    Starch propanoate used as feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth and / or achieve faster weight gain.
    [2]
    The use as feed additive and / or feed ingredient according to claim 1, characterized by 5 - used to increase the utilization of the feed.
    [3]
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by being used to promote the development of the gastrointestinal tract including increasing the density and / or thickness of the intestinal membrane and / or increasing the amount of cells in the thumb wall and / or increasing the length of villi and / or the length of the intestine.
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by being used to reduce the need for the use of medicinal zinc and / or antibiotics.
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by for the prevention of intestinal infections.
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by - used to reduce mortality.
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by being used for the prevention of diarrhea in animal herds.
    The use as a feed additive and / or feed ingredient according to claim 1, wherein the short chain fatty acid esterified to the starch may be any combination and ratio - of the three SCFAs: acetic acid, propanoic acid, butanoic acid.
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by being used for mixing in milk for milk-fed calves or used for mixing in feed for newly weaned piglets.
    The use as a feed additive and / or feed ingredient according to claim 1, characterized by - used to support gram-negative bacteria.
    NEWS SURVEY REPORT - PATENT Application number; PA 2020 00169 i. [OJ non-searchable requirements (see box no. I).
    2. J Inventive unit is missing before the news survey (see box no. ID).
    A. CLASSIFICATION A23K 10/00 (version 2016.01), A61K 31/19 (version 2006.01), A61K 47/36 (version 2006.01), A61P 1/12 (version 2006.01) According to the International Patent Classification (IPC) B. => EXAMINATION AREA PCT minimum documentation examined (classification system followed by classification symbols) A23K Examined documentation in addition to PCT minimum Used electronic databases (name of database and possibly search terms) EPODOC, WPI, FULL TEXT ENGELSEPENSPENSPENSEPHELSPE possibly with an indication of relevant sections Relevant for requirement no.
    X Wi 95/13801 A1 (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL 1-10 RESEARCH ORGANIZATION) May 26, 1995 See [0346], Example 5, fig. 6-8, claims 24, 25, 34,41, 44 X Wo 02/62102 A (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH 1-10 ORGANIZATION) January 10, 2002. See claims 1, 12-13; page 5, lines 27-31, page 11, lines 1-7 XX] Additional documents are listed in the continuation of Box C.
    + Category of cited documents: "per Document published in the period between priority" A "Document representing the prior art (state of the art) without | 98 filing date.
    to anticipate novelty or significant separation. T "Document which is not in conflict with the application but npn Document cited in the application. Which is cited to understand the basic principle or theory. Ne 0. Behind the invention.
    "E" Document that has a submission or priority date that is before on. . the filing date of the processed application, but which is X Particularly relevant document; the invention is not new or published later than the filing date. does not differ significantly from the prior art when the document "L" Document which may cast doubt on an alleged priority requirement or which is assessed alone. . Lo quoted to determine the date of publication of another document, or quoted by | "Y" - Particularly relevant document; the invention does not differ from other causes (as specified). substantially from prior art when the document is combined. Lo. with one or more documents of the same kind, and the combination of "o" Document dealing with non-written publication, eg lecture, | these are close to the expert exhibitions or films. . oo "&" Document in the same patent family.
    The Danish Patent and Trademark Office Date of completion of the news survey Helgeshøj Allé 81 23 February 2020 2630 Taastrup Telephone no. +45 4350 8000 The news survey was carried out by Telephone no. 43 50 83 75 January 2019 1
    Application number NEWS SURVEY REPORT - PATENT r PA 2020 00169 C (Continued). RELEVANT DOCUMENTS Cited documents with indication of relevant sections Relevant to requirements + no.
    A DI FILIPPO S. et al. "Organocatalytic route for the synthesis of propionylated starch", 1-10 CARBOHYDRATE POLYMERS, 2015, vol. 137, pages 198-206. See abstract; page 199, left column, 2nd paragraph; page 200, Results and discussion, 3.1 I -tartaric acid-catalyzed propionylation of starch Link for one time print: https: // www. renrintsdesk. com / landino / dl.ssøx70 = 67726548r = 23531912 £ 5 A ANNISON G. et al. "Acetylated, propionylated or butyrylated starches raise large bowel 1-10 short-chain fatty acids preferably when fed to rats. ” THE JOURNAL OF NUTRITION, 2003, vol. 133, no. 11, pages 3523-3528. The abstract. https: //www.nchi nim.nih gov / pubmed / tenn = 14608068 A HEDEMANN M.
    S. et al. “Resistant starch for weaning pigs - Effect on concentration of 1-10 short chain fatty acids in digesta and intestinal morphology”, LIVESTOCK SCIENCE, 2007, vol. 108, nos. 1-3, pages 175-177. See abstract and page 177, left column, section just above "Discussion" Link for one time print: https: // www. reprintsdesk com / landing / dl.aspx70 = 677 26568r = 6996601 28 January 2019 2
    NEWS SURVEY REPORT - PATENT Application number | PA 2020 00169 Box no. I Non-searchable requirements The news survey has not been conducted for the following requirements:
    Requirement No: because they relate to the derogations and therefore do not require a novelty, specifically:
    Requirements or. because they relate to parts of the patent application that do not live up to BEK $ 13 to such an extent that a meaningful news study cannot be conducted, specifically:
    3.0 Requirements or. for other reasons: Box no. II Inventive unit missing before the news survey Several inventions have been identified in the application: January 2019 3
    Application number NEWS SURVEY REPORT - PATENT PA 2020 00169
    SUPPLEMENTARY BOX Continuation of box no. [.] January 2019 4
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    同族专利:
    公开号 | 公开日
    WO2021160227A1|2021-08-19|
    DK180688B1|2021-11-26|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    EP0730447B1|1993-11-17|2002-02-20|Commonwealth Scientific And Industrial Research Organisation|Fatty acid delivery system|
    CN107156431A|2017-05-09|2017-09-15|全椒县鮰鱼养殖专业合作社|It is a kind of to improve the feed of channel catfish constitution|
    BE1025137B1|2017-12-22|2018-11-09|Nutri-Ad International Nv|ANIMAL FEED MATERIAL|
    CN108373984A|2018-04-09|2018-08-07|北京博锦元生物科技有限公司|A kind of Lactobacillus paracasei and its application|
    法律状态:
    2021-11-26| PAT| Application published|Effective date: 20210812 |
    2021-11-26| PME| Patent granted|Effective date: 20211126 |
    优先权:
    申请号 | 申请日 | 专利标题
    DKPA202000169A|DK180688B1|2020-02-11|2020-02-11|Starch propanoate used as feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth and / or achieve faster weight gain|DKPA202000169A| DK180688B1|2020-02-11|2020-02-11|Starch propanoate used as feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth and / or achieve faster weight gain|
    PCT/DK2020/050407| WO2021160227A1|2020-02-11|2020-12-27|Starch propionate to promote growth and/or to obtain a faster weight gain and/or to enhance feed utilization and/or to enhance the development of the gastrointestinal tract used as feed additive or feed ingredient for agricultural animals and aquaculture animals|
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